Bed bugs are persistent pests that disrupt sleep and invade homes, demanding powerful solutions like Crossfire bed bug sprays. Renowned for their dual-action formulas, these products, available on Amazon.com, effectively target pyrethroid-resistant bed bugs and their eggs, delivering fast knockdown and long-lasting residual control. The article “11 Best Crossfire Bed Bug Sprays” reviews top options, highlighting key features, pros, cons, and value to guide homeowners in selecting the ideal spray for eliminating infestations and restoring peace of mind.
1. MGK Crossfire Bed Bug Concentrate (13 oz)

MGK Crossfire Bed Bug Concentrate (13 oz) is a professional-grade liquid insecticide designed to combat pyrethroid-resistant bed bugs. Combining clothianidin, metofluthrin, and piperonyl butoxide, it kills all life stages, including eggs, within minutes. Ideal for indoor use, it offers up to 30 days of residual control and is non-staining, making it safe for mattresses and furniture.
Key Features
- Clothianidin, metofluthrin, piperonyl butoxide.
- Liquid concentrate, mixed with water for spraying.
- Up to 30 days of protection.
- 13 oz treats up to 1,000 square feet.
- Targets bed bugs, including resistant strains and eggs.
Pros
- Kills bed bugs within 5 minutes of contact.
- Long-lasting residual control for a month.
- Non-staining and low-odor formula.
- Safe for mattresses and upholstered furniture.
- Effective against pyrethroid-resistant strains.
Cons
- Requires mixing with water and a sprayer.
Why You Should Buy This Product
MGK Crossfire Bed Bug Concentrate (13 oz) is a top-tier solution for severe bed bug infestations. Its dual-action formula, with clothianidin and metofluthrin, ensures rapid knockdown and residual control for up to 30 days. Safe for indoor use on mattresses and furniture, it’s non-staining and low-odor, ideal for homes with pets and kids once dry. Perfect for large areas, this concentrate offers professional-grade results, making it a cost-effective choice for eliminating resistant bed bugs.
2. MGK Crossfire Aerosol (17 oz)

MGK Crossfire Aerosol (17 oz) is a ready-to-use spray that targets pyrethroid-resistant bed bugs and their eggs. With clothianidin, metofluthrin, and piperonyl butoxide, it delivers fast-acting results and up to four weeks of residual control. Its foaming application is ideal for cracks and crevices, making it suitable for indoor use in homes and commercial spaces.
Key Features
- Clothianidin, metofluthrin, piperonyl butoxide
- Aerosol spray with a straw tip for precision.
- Up to 4 weeks of protection.
- 17 oz can for targeted applications.
- Kills bed bugs and their eggs.
Pros
- Ready-to-use, no mixing required.
- Foaming spray reaches deep into crevices.
- Effective against resistant bed bug strains.
- Non-staining on water-safe surfaces.
- Fast-acting, kills on contact.
Cons
- Foam application may leave visible residue on dark surfaces.
Why You Should Buy This Product
MGK Crossfire Aerosol (17 oz) is perfect for quick, targeted bed bug control. It’s ready-to-use foaming spray, powered by clothianidin and metofluthrin, penetrates cracks and crevices, killing resistant bed bugs and eggs on contact. With up to four weeks of residual protection, it’s ideal for small infestations or spot treatments in homes. The straw tip ensures precise application, making it a convenient, effective choice for those needing immediate results without mixing.
3. Crossfire Bed Bug Concentrate (130 oz)

Crossfire Bed Bug Concentrate (130 oz) is a bulk option for large-scale bed bug treatments. Featuring clothianidin and metofluthrin, it provides fast knockdown and residual control for up to 30 days. Designed for professional use, it’s ideal for apartments, hotels, or severe infestations, offering cost-effective coverage for large areas.
Key Features
- Clothianidin, metofluthrin, piperonyl butoxide.
- Liquid concentrate for sprayer application.
- Up to 30 days of protection
- 130 oz treats up to 10,000 square feet
- Targets bed bugs, including eggs and resistant strains.
Pros
- Economical for large-scale treatments.
- Fast-acting with long-lasting residual effects.
- Non-staining and low-odor formula.
- Approved for use on mattresses and furniture.
- Effective against all bed bug life stages.
Cons
- Requires a sprayer and precise mixing.
Why You Should Buy This Product
Crossfire Bed Bug Concentrate (130 oz) is ideal for tackling large or persistent bed bug infestations. Its potent formula, combining clothianidin and metofluthrin, ensures rapid elimination and up to 30 days of residual control. Perfect for apartments or commercial spaces, it’s non-staining and safe for mattresses. This bulk option offers significant savings for extensive treatments, making it a go-to for professionals or homeowners with severe pest issues needing comprehensive coverage.
4. Crossfire Bed Bug Concentrate with USA Supply Gloves (13 oz)

Crossfire Bed Bug Concentrate (13 oz) with USA Supply Gloves includes the same powerful concentrate as the standard 13 oz version, plus gloves for safe application. It kills pyrethroid-resistant bed bugs and eggs with a dual-action formula, offering up to 30 days of residual control for indoor use.
Key Features
- Clothianidin, metofluthrin, piperonyl butoxide
- Liquid concentrate with included gloves.
- Up to 30 days of protection.
- 13 oz treats up to 1,000 square feet.
- Multi-Pest: Targets bed bugs and their eggs.
Pros
- Includes gloves for safe handling.
- Fast knockdown within 5 minutes.
- Non-staining and low-odor formula.
- Effective against resistant strains.
- Suitable for mattresses and furniture.
Cons
- Requires mixing and a sprayer.
Why You Should Buy This Product
Crossfire Bed Bug Concentrate with USA Supply Gloves (13 oz) combines a powerful insecticide with added safety. Its clothianidin and metofluthrin formula kills resistant bed bugs and eggs quickly, with residual protection for 30 days. The included gloves ensure safe application, making it ideal for homeowners tackling indoor infestations. Non-staining and low-odor, it’s perfect for mattresses and furniture, offering a reliable, user-friendly solution for effective bed bug control.
5. Crossfire Bed Bug Aerosol with USA Supply Gloves (17 oz)

Crossfire Bed Bug Aerosol (17 oz) with USA Supply Gloves is a ready-to-use spray with included gloves for safe application. Its foaming formula targets pyrethroid-resistant bed bugs and eggs, penetrating crevices for fast and effective action. It offers up to four weeks of residual control.
Key Features
- Clothianidin, metofluthrin, piperonyl butoxide.
- Aerosol spray with a straw tip and gloves.
- Up to 4 weeks of protection.
- 17 oz can for targeted applications.
- Kills bed bugs and their eggs.
Pros
- Ready-to-use with no mixing required.
- Includes gloves for safe application.
- Foaming spray reaches hidden areas.
- Non-staining on water-safe surfaces.
- Effective against resistant strains.
Cons
- Limited coverage compared to concentrates.
Why You Should Buy This Product
Crossfire Bed Bug Aerosol with USA Supply Gloves (17 oz) is a convenient, effective solution for bed bug control. It’s a foaming spray, powered by clothianidin and metofluthrin, kills resistant bed bugs and eggs on contact, with up to four weeks of residual protection. The included gloves ensure safe application, and the straw tip targets crevices. Ideal for small infestations or spot treatments, this product offers quick, reliable results for homeowners seeking hassle-free pest control.
6. Crossfire Bed Bug Concentrate (16 oz)

Crossfire Bed Bug Concentrate (16 oz) is a slightly larger version of the standard concentrate, offering the same dual-action formula with clothianidin and metofluthrin. It provides fast knockdown and 30-day residual control, ideal for indoor use in homes and commercial spaces.
Key Features
- Clothianidin, metofluthrin, piperonyl butoxide.
- Liquid concentrate for sprayer application.
- Up to 30 days of protection.
- 16 oz treats up to 1,200 square feet.
- Targets bed bugs and their eggs.
Pros
- Fast-acting with long-lasting effects.
- Non-staining and low-odor formula.
- Safe for mattresses and furniture.
- Effective against resistant strains.
- Slightly larger size than the 13 oz version.
Cons
- Not suitable for outdoor use.
Why You Should Buy This Product
Crossfire Bed Bug Concentrate (16 oz) offers a robust solution for bed bug infestations. Its clothianidin and metofluthrin formula ensures rapid elimination of resistant bed bugs and eggs, with 30 days of residual protection. Non-staining and low-odor, it’s safe for indoor use on mattresses and furniture. Ideal for medium-sized infestations, this concentrate provides professional-grade results, making it a reliable choice for homeowners seeking effective, long-term bed bug control.
7. Crossfire Bed Bug Concentrate (2 x 13 oz Bottles)

Crossfire Bed Bug Concentrate (2 x 13 oz Bottles) is a dual-pack option for tackling moderate bed bug infestations. Featuring clothianidin, metofluthrin, and piperonyl butoxide, it delivers fast knockdown and 30-day residual control. Ideal for indoor use, it’s non-staining and safe for mattresses, making it a practical choice for homeowners.
Key Features
- Clothianidin, metofluthrin, piperonyl butoxide.
- Liquid concentrate for sprayer application
- Up to 30 days of protection.
- 26 oz total treats up to 2,000 square feet.
- Kills bed bugs, including eggs and resistant strains.
Pros
- Dual-pack offers value for larger treatments.
- Fast-acting, kills within 5 minutes.
- Non-staining and low-odor formula.
- Safe for mattresses and furniture.
- Effective against pyrethroid-resistant bed bugs.
Cons
- Not suitable for outdoor use in wet conditions.
Why You Should Buy This Product
Crossfire Bed Bug Concentrate (2 x 13 oz Bottles) is an excellent choice for homeowners dealing with moderate bed bug infestations. Its dual-action formula, combining clothianidin and metofluthrin, ensures rapid elimination of resistant bed bugs and eggs, with 30 days of residual protection. Non-staining and low-odor, it’s safe for indoor use on mattresses and furniture. The dual-pack provides ample coverage for larger areas, offering cost-effective, professional-grade results for those needing thorough pest control.
8. Crossfire Bed Bug Aerosol Case (12 x 17 oz Cans)

Crossfire Bed Bug Aerosol Case (12 x 17 oz Cans) is a bulk option for ready-to-use aerosol sprays. Featuring clothianidin and metofluthrin, it targets resistant bed bugs and eggs, offering up to four weeks of residual control. Ideal for spot treatments or small infestations.
Key Features
- Clothianidin, metofluthrin, piperonyl butoxide.
- Aerosol spray with straw tip.
- Up to 4 weeks of protection.
- 12 cans for multiple applications.
- Kills bed bugs and their eggs.
Pros
- Ready-to-use, no mixing required.
- Foaming spray reaches crevices.
- Effective against resistant strains.
- Non-staining on water-safe surfaces.
- Convenient for spot treatments.
Cons
- Higher cost per ounce than concentrates.
Why You Should Buy This Product
Crossfire Bed Bug Aerosol Case (12 x 17 oz Cans) offers a convenient, ready-to-use solution for bed bug control. It’s a foaming spray, with clothianidin and metofluthrin, that kills resistant bed bugs and eggs on contact, with four weeks of residual protection. Perfect for spot treatments or small infestations, the straw tip ensures precise application in crevices. This bulk option is ideal for ongoing maintenance, providing reliable, non-staining results for homeowners seeking effective pest control.
9. STEM Kills Ants, Roaches and Flies, 12 fl oz (Pack Of 1)

STEM Kills Ants, Roaches, and Flies is a plant-based insecticide designed for indoor and outdoor use. Formulated with botanical extracts like geraniol and lemongrass oil, this 12 fl oz spray targets ants, roaches, and flies, offering a non-toxic alternative to traditional pesticides. Safe for use around people and pets when used as directed, it’s ideal for kitchens, homes, and gardens, providing a fresh scent without harsh chemical odors. This USA-made product, available on Amazon.com, is entomologist-tested for effective pest control.
Key Features
- Geraniol (6.2%), lemongrass oil (0.5%).
- Ready-to-use spray for indoor and outdoor surfaces.
- 12 fl oz for targeted applications.
- Non-toxic, safe around people and pets when used as directed
- Kills ants (e.g., carpenter, Argentine), roaches (e.g., German, American), and flies.
Pros
- Plant-based formula is safe for households with pets and children.
- Pleasant, fresh scent with no harsh chemical odors.
- Effective on contact for ants, roaches, and flies.
- Easy-to-use spray bottle for precise application.
- Entomologist-tested for reliable pest control.
Cons
- Leaves oily residue on surfaces, potentially slippery.
Why You Should Buy This Product
STEM Kills Ants, Roaches, and Flies (12 fl oz) is an eco-friendly solution for homeowners seeking safe, effective pest control. It’s plant cesta-based formula, featuring geraniol and lemongrass oil, kills ants, roaches, and flies on contact while being non-toxic and safe around pets and kids when used as directed. The ready-to-use spray is versatile for indoor and outdoor use, with a pleasant botanical scent. Ideal for kitchens and gardens, it offers quick results without harsh chemicals. Despite needing reapplication for severe infestations, it’s a reliable choice for sustainable pest management.
10. Ortho Home Defense Max Indoor Insect Barrie, 1 gal.

Ortho Home Defense Max Indoor Insect Barrier with Extended Reach Comfort Wand is a powerful, ready-to-use insecticide designed to combat a wide range of household pests, including ants, roaches, spiders, fleas, ticks, and earwigs. Featuring bifenthrin (0.05%) as its active ingredient, this 1-gallon spray creates a long-lasting barrier, offering up to 12 months of protection indoors and 3 months outdoors on non-porous surfaces. Its fast-drying, odorless formula and ergonomic Comfort Wand make it ideal for indoor and perimeter applications, ensuring effective pest control without staining or fumes. Available on Amazon.com, this USA-made product is a top choice for homeowners seeking reliable, long-term pest management.
Key Features
- Bifenthrin (0.05%) for broad-spectrum pest control.
- Ready-to-use spray with Extended Reach Comfort Wand.
- Up to 12 months indoors, 3 months outdoors on non-porous surfaces.
- 1 gallon treats large areas, including kitchens, bathrooms, and home perimeters.
- Kills ants, roaches, spiders, fleas, ticks, scorpions, beetles, earwigs, and more.
Pros
- Long-lasting protection, up to 12 months indoors.
- Easy-to-use Comfort Wand with continuous spray reduces hand fatigue.
- Odorless and non-staining formula safe for indoor use.
- Kills a wide range of pests on contact.
- Suitable for both indoor and outdoor perimeter applications.
Cons
- Not safe for use on edible plants or near water sources.
Why You Should Buy This Product
Ortho Home Defense Max Indoor Insect Barrier (1 gal.) is a top-tier solution for homeowners battling persistent pests like ants, roaches, and earwigs. It’s a bifenthrin-based formula that delivers fast-acting results, killing pests on contact while creating a protective barrier that lasts up to 12 months indoors. The Extended Reach Comfort Wand ensures precise, effortless application in hard-to-reach areas like cracks and crevices. Safe for use around pets and kids once dry, its odorless, non-staining formula is ideal for kitchens, bathrooms, and perimeters. For reliable, long-lasting pest control, Ortho Home Defense Max is a trusted, effective choice.
11. Grandpa Gus’s Natural Bed Bug Killer Spray,16 fl oz

Grandpa Gus’s Natural Bed Bug Killer Spray is a non-aerosol, plant-based insecticide designed to eliminate bed bugs and their eggs, including pyrethroid-resistant strains. Formulated with geraniol, lemongrass oil, citronella oil, and sodium lauryl sulfate, this 16 fl oz spray offers up to 48 hours of time-release protection. Safe for use around kids and pets when used as directed, it’s ideal for indoor applications on mattresses, bed frames, and crevices.
Key Features
- Geraniol (6.0%), lemongrass oil (0.5%), citronella oil (0.5%), and sodium lauryl sulfate (1.0%).
- Ready-to-use, non-aerosol spray for indoor use.
- Residual Effect: Up to 48 hours of time-release protection.
- 16 fl oz for targeted applications on mattresses, furniture, and crevices.
- Kills bed bugs, pyrethroid-resistant bed bugs, and their eggs.
Pros
- Plant-based formula is safe for kids and pets when used as directed.
- Non-staining and won’t harm fabrics like mattresses or upholstery.
- Pleasant lemongrass and citronella scent, no harsh chemical odors.
- Effective against resistant bed bug strains and eggs.
- Easy-to-use spray bottle for precise application.
Cons
- May require multiple applications for heavy infestations.
Why You Should Buy This Product
Grandpa Gus’s Natural Bed Bug Killer Spray (16 fl oz) is an eco-friendly choice for homeowners seeking a safe, effective solution to bed bug infestations. Its plant-based formula, with geraniol, lemongrass, and citronella oils, kills bed bugs and their eggs on contact, including resistant strains, while offering 48 hours of time-release protection. Safe for use around kids and pets once dry, it’s ideal for mattresses, bed frames, and crevices. The non-staining, fresh-scented spray is perfect for those prioritizing natural pest control, though heavy infestations may require repeated applications for complete eradication.
